ELASA for Dengue Detection

Universiti Sains Malaysia
Socio-Economics Driver
Science & Technology Driver
Bioscience Technology
Technology Readiness Level
Intellectual Property

Cheaper system with no batch-to-batch variation associated with aptamer

1) Academia: Prototype is envisaged to be one of the steps in galvanizing the universal move to educate and proselytize on the application of aptamers in diagnostics

2) Economy: Aptamers are cheaper compared to antibodies. Integrating aptamers into lateral flow assays as the surrogates of the traditional antibodies as a whole would minimize the overall cost of production

3) Industry: The kit could provide revenues that can be benefitted by the kit developers, distributors or even sales individuals.

4) Community: To promote the usage of aptamer-based system among the community based on the advantages of the aptamers

5) Environment: The application of aptamers as a non-harmful element in ELISA

1) Dengue infection is prevalent in Asian countries, contributing to 70% of the global burden

2) Specifically, ASEAN countries have reported an increase of 46% in dengue cases from 2015 to 2019

3) In Malaysia alone- more 200% increase in 2023

1) For better disease management, rapid diagnostics are needed (Direct Detection)

2) Direct detection of NS1 is based on the usage of antibodies

3) Molecular Recognition Element: Aptamers

1) Aptamer can be synthesized at a large scale at a much cheaper price as compared to antibodies

2) Aptamers show no batch-to-batch

Project

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