A Scaffold Composition for Use in Wound Management

Universiti Tun Hussein Onn Malaysia
Socio-Economics Driver
Medical & Healthcare
Science & Technology Driver
Advanced Materials
Technology Readiness Level
6
Intellectual Property
MY-203419-A

Unlike conventional wound dressings, this scaffold integrates a nanofibre structure with a natural bioactive compound to provide both physical support and therapeutic function. This combination may enhance wound healing by promoting tissue regeneration, reducing inflammation, and maintaining a biocompatible and conducive environment for recovery.

Chronic wounds and infected wounds are often slow to heal and require frequent medical attention and dressing changes. Many conventional wound dressings primarily serve as protective coverings and do not actively promote tissue regeneration or effectively reduce inflammation, which can further delay the healing process.

The scaffold is produced using electrospinning to form a porous nanofibre structure that closely mimics the natural extracellular matrix. Bromelain, a natural proteolytic enzyme, is incorporated into the fibres and released in a controlled manner over time. This sustained release helps reduce inflammation, support tissue repair, and promote faster wound healing.

The project innovates a PVA-based electrospun nanofibre scaffold loaded with bromelain for wound care. Unlike conventional dressings, it provides both structural support and active healing benefits by mimicking the extracellular matrix and enabling controlled release of anti-inflammatory compounds. This promotes faster, more effective healing of chronic and infected wounds.

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